tailieunhanh - Báo cáo y học: "Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice. | Corson et al. Allergy Asthma Clinical Immunology 2010 6 7 http content 6 1 7 ALLERGY ASTHMA CLINICAL IMMUNOLOGY RESEARCH Open Access Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice Lin Corson 1 Huaijie Zhu1 Chunli Quan2 Gabriele Grunig1 2 Manisha Ballaney1 Ximei Jin2 Frederica P Perera3 Phillip H Factor1 Lung-Chi Chen2 and Rachel L Miller 1 2 Abstract Background Multiple studies have suggested that prenatal exposure to either allergens or air pollution may increase the risk for the development of allergic immune responses in young offspring. However the effects of prenatal environmental exposures on adult offspring have not been well-studied. We hypothesized that combined prenatal exposure to Aspergillus fumigatus A. fumigatus allergen and diesel exhaust particles will be associated with altered IgE production airway inflammation airway hyperreactivity AHR and airway remodeling of adult offspring. Methods Following sensitization via the airway route to A. fumigatus and mating pregnant BALB c mice were exposed to additional A. fumigatusand or diesel exhaust particles. At age 9-10 weeks their offspring were sensitized and challenged with A. fumigatus. Results We found that adult offspring from mice that were exposed to A. fumigatus or diesel exhaust particles during pregnancy experienced decreases in IgE production. Adult offspring of mice that were exposed to both A. fumigatus and diesel exhaust particles during pregnancy experienced decreases in airway eosinophilia. Conclusion These results suggest that in this model allergen and or diesel administration during pregnancy may be associated with protection from developing systemic and airway allergic immune responses in the adult offspring. Background Epidemiological studies and murine models suggest that prenatal environmental exposures can enhance the risk for developing asthma in the offspring 1 2 . In humans prenatal exposures to air .