tailieunhanh - Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" High blood pressure, antihypertensive medication and lung function in a general adult population. | Schnabel et al. Respiratory Research 2011 12 50 http content 12 1 50 RESPIRATORY RESEARCH RESEARCH Open Access High blood pressure antihypertensive medication and lung function in a general adult population 12 - Z-I 6 Eva Schnabel Stefan Karrasch Holger Schulz Sven Glaser Christa Meisinger Margit Heier Annette Peters8 11 H-Erich Wichmann1 8 Jurgen Behr5 9 Rudolf M Huber5 10 and Joachim Heinrich1 for for the Cooperative Health Research in the Region of Augsburg KORA Study Group Abstract Background Several studies showed that blood pressure and lung function are associated. Additionally a potential effect of antihypertensive medication especially beta-blockers on lung function has been discussed. However side effects of beta-blockers have been investigated mainly in patients with already reduced lung function. Thus aim of this analysis is to determine whether hypertension and antihypertensive medication have an adverse effect on lung function in a general adult population. Methods Within the population-based KORA F4 study 1319 adults aged 40-65 years performed lung function tests and blood pressure measurements. Additionally information on anthropometric measurements medical history and use of antihypertensive medication was available. Multivariable regression models were applied to study the association between blood pressure antihypertensive medication and lung function. Results High blood pressure as well as antihypertensive medication were associated with lower forced expiratory volume in one second p respectively p R2 and forced vital capacity values p respectively p R2 . Furthermore a detailed analysis of antihypertensive medication pointed out that only the use of beta-blockers was associated with reduced lung function whereas other antihypertensive medication had no effect on lung function. The adverse effect of beta-blockers was significant for forced vital capacity p R2 .