tailieunhanh - Chồng lấp hội chứng Stevens - Johnson và hoại tử thượng bì nhiễm độc do thuốc thiabendazole: Trường hợp lâm sàng

Bài viết trình bày mô tả chồng lấp hội chứng Stevens - Johnson và hoại tử thượng bì nhiễm độc trên lâm sàng. Đối tượng và phương pháp: Chúng tôi báo cáo trường hợp bệnh nhân nữ 46 tuổi bị phát ban bóng nước và trợt da lan rộng toàn thân 25 ngày sau khi uống thuốc thiabendazole điều trị bệnh nhiễm ấu trùng Toxocara spp. từ bệnh viện tuyến trước. | Vietnam Journal of Community Medicine Vol. 64 Special Issue 2023 1-8 INSTITUTE OF COMMUNITY HEALTH OVERLAPPING STEVENS - JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS CAUSED BY THIABENDAZOLE CASE REPORT Le Dinh Vinh Phuc Tran Tan Hung Phan Thanh Hai Medic Medical Center HCMC - 254 Hoa Hao 4 ward 10 district Ho Chi Minh City Vietnam Received 15 12 2022 Revised 10 01 2023 Accepted 16 02 2023 ABSTRACT Objective To describe the overlapping of Stevens - Johnson syndrome and toxic epidermal necrolysis in clinical. Subjects and methods We report the case of a 46 - year - old female patient who developed a bullous rash and extensive skin erosion 25 days after taking thiabendazole to treat Toxocara spp. from the other hospital. Results The skin detachment of body surface area calculated according to the rule of 9 was about 21 face 3 abdomen 9 back 9 . The SCORTEN scale assessed at admission was 2 points with a mortality rate of . The ALDEN algorithm for finding drug - related causality reached 4 points showing that thiabendazole was the drug that likely to cause overlapping Stevens - Johnson syndrome and toxic epidermal necrolysis in the patient. She was treated with antibiotics anti - inflammatory drugs vitamins nutritional support and wound care. The treatment results were completely recovered and discharged after 3 weeks leaving no sequelae of skin mucous membranes and organ functions. Conclusion The overlapping of Stevens - Johnson syndrome and toxic epidermal necrolysis is a delayed hypersensitivity reaction characterized by extensive bullous lesions erosive ulcers and severe mucosal and skin necrosis that can lead to death. Thiabendazole is an antiparasitic drug that has been reported to cause Stevens - Johnson syndrome and toxic epidermal necrolysis although rarely. Keywords Thiabendazole overlapping Stevens - Johnson and toxic epidermal necrolysis. Corressponding author Email address bsvinhphuc1981@ Phone number 84 982 102 262 1 . Phuc et al. .