tailieunhanh - Báo cáo khoa học: "Tongue carcinoma in an adult Down's syndrome patient: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Tongue carcinoma in an adult Down's syndrome patient: a case report | BioMed Central World Journal of Surgical Oncology Open Access Case report Tongue carcinoma in an adult Down s syndrome patient a case report Fadi S Farhat 1 2 Fady Geara3 Mohamed Natout3 Jamal Serhal1 and Walid Daya1 Address 1Hammoud Hospital University Medical Center Saida Lebanon 2Mount Lebanon Hospital Beirut Lebanon and 3American University Hospital Beirut Lebanon Email Fadi S Farhat - drfadi@ Fady Geara - fg00@ Mohamed Natout - mn47@ Jamal Serhal - Walid Daya - drwdayeh@ Corresponding author Published 4 March 2009 Received 16 May 2008 World Journal of Surgical Oncology 2009 7 26 doi l477-78l 9-7-26 Accepted 4 March 2009 This article is available from http content 7 l 26 2009 Farhat et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cancer of the oral cavity is rare and unusual in Down s syndrome patient. The over all risk is similar to that in adult population. Case presentation This case report describes a 27 years old male with Down s syndrome nonsmoker who developed a poorly differentiated squamous cell carcinoma of the tongue. The patient underwent a hemiglossectomy without neck dissection followed by a postoperative locoregional radiation therapy to a total tumor-bed dose of 56 Gy and 45 Gy to the neck. Three months later the patient presented with local tongue recurrence and was treated by Docetaxel and Carboplatin chemotherapy with no significant response. The patient died one month later 9 months after his initial diagnosis. Conclusion To our knowledge this is the first case of tongue carcinoma arising in a patient with Down s syndrome. This unique case might not be sufficient to make a significant .