tailieunhanh - The effects of ionic strength and temperature on the dissociation constants of adefovir and cidofovir used as antiviral drugs

The effects of ionic strength and temperature on the dissociation constants of adefovir (PMEA) and cidofovir (HPMPC) used as antiviral drugs were studied at 298 K, 308 K, and 318 K in aqueous media and at different ionic strength backgrounds of NaCl potentiometrically. The dissociation constants of the ligands were determined via the calculation of the titration data with the SUPERQUAD computer program. The thermodynamic parameters (∆G, ∆H , and ∆S) for all species were calculated. The dissociation order of nitrogen and oxygen atoms in the ligands according to proton affinities values were obtained using PM6 semiempirical methods. |

TỪ KHÓA LIÊN QUAN
TÀI LIỆU MỚI ĐĂNG
20    114    0    27-06-2024