tailieunhanh - Báo cáo y học: " Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IκBα and enhances HIV-1 replication in human T lymphocytes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IκBα and enhances HIV-1 replication in human T lymphocytes. | Retrovirology BioMed Central Open Access Caspase-3-mediated cleavage of p65 RelA results in a carboxy-terminal fragment that inhibits IKBa and enhances HIV-1 replication in human T lymphocytes Mayte Coiras María Rosa Lopez-Huertas Elena Mateos and José Alcamí Address AIDS Immunopathology Unit National Center of Microbiology Instituto de Salud Carlos III 28220 Majadahonda Madrid Spain Email Mayte Coiras - mcoiras@ María Rosa López-Huertas - mrlhuertas@ Elena Mateos - emateo@ José Alcamí - ppalcami@ Corresponding authors Published I December 2008 Received 4 July 2008 Retrovirology 2008 5 109 doi 1742-4690-5-109 Accepted 1 December 2008 This article is available from http content 5 I I09 2008 Coiras et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Degradation of p65 RelA has been involved in both the inhibition of NF-kB-dependent activity and the onset of apoptosis. However the mechanisms of NF-kB degradation are unclear and can vary depending on the cell type. Cleavage of p65 RelA can produce an aminoterminal fragment that was shown to act as a dominant-negative inhibitor of NF-kB thereby promoting apoptosis. However the opposite situation has also been described and the production of a carboxy-terminal fragment that contains two potent transactivation domains has also been related to the onset of apoptosis. In this context a carboxy-terminal fragment of p65 RelA ANH2p65 detected in non-apoptotic human T lymphocytes upon activation has been studied. T cells constitute one of the long-lived cellular reservoirs of the human immunodeficiency virus type 1 HIV-1 . Because NF-kB is the most important inducible element involved in initiation .