tailieunhanh - Báo cáo y học: "Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis. | Liu et al. Arthritis Research Therapy 2010 12 R210 http content 12 6 R210 RESEARCH ARTICLE Open Access Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis 1t 1t 1 1 11 1 1 1 Yanying Liu Rong Mu Shiyao Wang Li Long Xia Liu Ru Li Jian Sun Jianping Guo Xiaoping Zhang Jing Guo1 Ping Yu1 Chunlei Li1 Xiangyuan Liu2 Zhenyu Huang3 Dapeng Wang3 Hu Li4 Zhifeng Gu5 Bing Liu6 Zhanguo Li1 Abstract Introduction Rheumatoid arthritis RA is a T-cell-mediated systemic autoimmune disease characterized by synovium inflammation and articular destruction. Bone marrow mesenchymal stem cells MSCs could be effective in the treatment of several autoimmune diseases. However there has been thus far no report on umbilical cord UC -MSCs in the treatment of RA. Here potential immunosuppressive effects of human UC-MSCs in RA were evaluated. Methods The effects of UC-MSCs on the responses of fibroblast-like synoviocytes FLSs and T cells in RA patients were explored. The possible molecular mechanism mediating this immunosuppressive effect of UC-MSCs was explored by addition of inhibitors to indoleamine 2 3-dioxygenase IDO Nitric oxide NO prostaglandin E2 PGE2 transforming growth factor P1 TGF-P1 and interleukin 10 IL-10 . The therapeutic effects of systemic infusion of human UC-MSCs on collagen-induced arthritis CIA in a mouse model were explored. Results In vitro UC-MSCs were capable of inhibiting proliferation of FLSs from RA patients via IL-10 IDO and TGF-P1. Furthermore the invasive behavior and IL-6 secretion of FLSs were also significantly suppressed. On the other hand UC-MSCs induced hyporesponsiveness of T cells mediated by PGE2 TGF-P1 and NO and UC-MSCs could promote the expansion of CD4 Foxp3 regulatory T cells from RA patients. More importantly systemic infusion of human UC-MSCs reduced the severity of CIA in a mouse model. Consistently there were reduced levels of proinflammatory cytokines and chemokines .