tailieunhanh - báo cáo khoa học: "Heterotopic ossification after patellar tendon repair in a man with trisomy 8 mosaicism: a case report and literature review"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Heterotopic ossification after patellar tendon repair in a man with trisomy 8 mosaicism: a case report and literature review | Chen and Chmell Journal of Medical Case Reports 2011 5 453 http content 5 1 453 JOURNALOF medical Ur Case REPORTS CASE REPORT Open Access Heterotopic ossification after patellar tendon repair in a man with trisomy 8 mosaicism a case report and literature review Austin Chen and Samuel Chmell Abstract Introduction Heterotopic ossification is the abnormal formation of lamellar bone in soft tissue. Its presence jeopardizes functional outcome impairs rehabilitation and increases costs due to subsequent surgical interventions. Case presentation We present a case of a 32-year-old African-American man with trisomy 8 mosaicism who developed severe heterotopic ossification of his right extensor mechanism subsequent to repair of a patellar tendon rupture. Conclusion To the best of our knowledge there are no prior reports of heterotopic ossification as a complication of patellar tendon repair. This case may suggest an association between trisomy 8 mosaicism and increased risk of heterotopic ossification. Introduction Heterotopic ossification HO is most commonly associated with musculoskeletal trauma central nervous system disorders or injuries severe burns and elective surgery such as total hip arthroplasty 1 . The clinical signs of HO include increased joint stiffness limited range of motion warmth swelling and erythema. Although its etiology is still unclear important contributing factors include hypercalcemia tissue hypoxia alterations in sympathetic nerve activity prolonged immobilization and imbalance between parathyroid hormone and calcitonin 2 . The overexpression of bone morphogenetic proteins BMPs among other systemic and local factors also appears to play an important role in the pathophysiology of HO 2 . HO occurs in 3-90 of lower limb joint replacement cases though only 3-7 is clinically significant based on the Brooker Classification of HO Grades 3 and 4 3 4 . HO can also be hereditary similar to fibrodysplasia ossificans progressiva .