tailieunhanh - Nghiên cứu bào chế bột cao khô NGL từ bài thuốc Nhất gan linh

Bài viết Nghiên cứu bào chế bột cao khô NGL từ bài thuốc Nhất gan linh trình bày việc xây dựng quy trình bào chế và đánh giá tiêu chuẩn chất lượng bột cao khô NGL trên cơ sở bài thuốc y học cổ truyền Nhất gan linh có tác dụng điều trị xơ gan bằng phương pháp phun sấy. | Vietnam Journal of Community Medicine Vol. 65 No. 2 127-134 INSTITUTE OF COMMUNITY HEALTH STUDY ON PREPARATION OF NGL POWDERED EXTRACT BASED ON NHAT GAN LINH TRADITIONAL MEDICINAL FORMULATION Pham Xuan Phong1 Chu Van Men2 Chu Duc Thanh3 Tran Thi Tuyet Nhung1 Bui Thi Bich Van2 Military Institute of Traditional Medicine - 442 Kim Giang Dai Kim Hoang Mai Hanoi Vietnam 1 Vietnam Military Medical University - 160 Phung Hung Phuc La Ward Ha Dong Hanoi Vietnam 2 3 Military Institute of Radiation Medicine and Cancer - 18 Dinh Cong Thuong Dinh Cong Hoang Mai Hanoi Vietnam Received 11 09 2023 Revised 12 12 2023 Accepted 30 01 2024 ABSTRACT Objectives To develop the preparation process and quality assessment of the NGL powdered extract which originates from the Nhat gan linh traditional medicine. Subjects and methods Preparation of NGL powdered extract including 15 medicinal materials Radix Glehniae Radix Rehmanniae glutinosae Radix Angelicae sinensis Fructus Meliae toosendan Polyporus Poria Rhizoma Alismatis Styli et stigmata Maydis Cortex Phellodendri Cortex Radicis Paeoniae suffruticosae Fructus Corni officinalis Fructus aurantii immaturus Radix Bupleuri chinensis Radix Eurycomae longifoliae Radix Paeoniae lactiflorae via hot extraction combined and spray-drying technique. The quality assessment of powdered extract included morphology density index compression index loss on drying. Results Liquid extract NGL 3 1 was prepared using extract solvent as water material solvent 1 6 g mL extraction temperature 700C extraction time 60 minutes repeated 2 times. The spray-drying parameters were determined mixure of spray-drying excipients maltodextrin aerosil 30 70 w w excipients extract solid 3 7 w w percentage of solid in spray solvent 15 spray-drying temperature 1400C speed of feed 30 ml min pump pressure Mpa. The spray-drying yield was recovery yield of saikosaponin A and berberin was and respectively. The quality parameters of NGL powdered extract .