tailieunhanh - Báo cáo y học: "Fish oil: what the prescriber needs to know"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Fish oil: what the prescriber needs to know. | Available online http content 8 1 202 Review Fish oil what the prescriber needs to know Leslie G Cleland Michael J James and Susanna M Proudman Rheumatology Unit Royal Adelaide Hospital North Terrace Adelaide Australia Corresponding author Michael James mjames@ Published 21 December 2005 This article is online at http content 8 1 202 2005 BioMed Central Ltd Arthritis Research Therapy 2006 8 202 doi ar1876 Abstract There is a general belief among doctors in part grounded in experience that patients with arthritis need nonsteroidal antiinflammatory drugs NSAIDs . Implicit in this view is that these patients require the symptomatic relief provided by inhibiting synthesis of nociceptive prostaglandin E2 a downstream product of the enzyme cyclo-oxygenase COX which is inhibited by NSAIDs. However the concept of safe NSAIDs has collapsed following a multiplicity of observations establishing increased risk for cardiovascular events associated with NSAID use especially but not uniquely with the new COX-2-selective NSAIDs. This mandates greater parsimony in the use of these agents. Fish oils contain a natural inhibitor of COX reduce reliance on NSAIDs and reduce cardiovascular risk through multiple mechanisms. Fish oil thus warrants consideration as a component of therapy for arthritis especially rheumatoid arthritis in which its symptomatic benefits are well established. A major barrier to the therapeutic use of fish oil in inflammatory diseases is ignorance of its mechanism range of beneficial effects safety profile availability of suitable products effective dose latency of effects and instructions for administration. This review provides an evidence-based resource for doctors and patients who may choose to prescribe or take fish oil. Introduction Essential dietary constituents are those that cannot be synthesized endogenously. Vitamins are familiar examples of essential micronutrients. The dietary .

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