tailieunhanh - Cải thiện chiều cao ở trẻ thiếu hụt hormon tăng trưởng được điều trị bằng hormon thay thế

Thiếu hormon tăng trưởng là nguyên nhân thường gặp gây tầm vóc thấp, được điều trị bằng phác đồ thay thế hormon tăng trưởng tái tổ hợp tiêm dưới da. Bệnh nhân thường đạt được vận tốc chiều cao tối đa trong năm đầu điều trị, sau đó sẽ giảm dần trong những năm sau cho đến khi ngừng điều trị. | Journal of Pediatric Research and Practice Vol. 5 No. 5 2021 47-53 Research Paper Effect of Growth Hormone Therapy on Height in Children with Growth Hormone Deficiency Vu Chi Dung1 Nguyen Thi Hang1 Nguyen Thu Ha1 Do Thi Thanh Mai1 Bui Phuong Thao1 Nguyen Ngoc Khanh1 Can Thi Bich Ngoc1 Nguyen Trong Thanh1 1 Vietnam National Children s Hospital 18 879 La Thanh Dong Da Hanoi Vietnam Received 20 July 2021 Revised 30 July 2021 Accepted 15 September 2021 Abstract Growth Hormone Deficiency GHD is a common cause of short stature treated with the standard regimen of subcutaneous synthetic growth hormone GH . Patients typically achieve a maximum height velocity in the first year of treatment which then tapers shortly after treatment is stopped. Objective To describe long-term outcomes of patients with GHD treated with rhGH. Methods The study described clinical feature laboratory indexes and clinical outcomes of 4 patients with growth hormone deficiency aged 17 - 111 months at the Viet Nam National Children s Hospital. All patients presented with short sature lt -4 SDS for age and sex basal hormone levels showed low serum IGF1 GH skeletal wrist age was younger than chronologic age cranial MRI revealed no masses 2 patients one patient have a small pitutary gland and one patient don t have the pitutary gland. GH supplementation was started and pursued for 2 - 6 years. Results Dramatically increased height velocity 14 - 18 cm in the first year gradually decreased in the following years. Significant catch-up growth occurred in all of them after 3 - 5 years. Conclusion Short sature was the main clinical symtom of children on set GHD in this case series. Early initiation of GH treatment in children with GHD improves their chance of achieving their normal height velocity. Keywords growth hormone deficiency short stature in children Corresponding author. E-mail address dungvu@ https 47 48 . Dung et al. Journal of Pediatric Research and .