tailieunhanh - In vitro effects of levosimendan on muscle of malignant hyperthermia susceptible and non-susceptible swine

The calcium sensitizer levosimendan is increasingly used to improve hemodynamics in patients with acutely decompensated heart failure. By binding to cardiac troponin C the conformation of the calcium-troponin C complex is stabilized, which leads to acceleration of actin-myosin crossbrigde formation and increased force generating capacity of muscle fibers. |

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