tailieunhanh - Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer

3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance (NMR). The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 (prostate carcinoma) cell lines. | Turkish Journal of Chemistry Turk J Chem 2021 45 192-198 http chem TÜBİTAK Research Article doi kim-2008-56 Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer 1 2 3 2 Metin YILDIRIM Mehmet ERSATIR Badel ARSLAN Elife Sultan GİRAY 1 Department of Pharmacy Services Vocational School of Health Services Tarsus University Mersin Turkey 2 Department of Chemistry Arts and Science Faculty Çukurova University Adana Turkey 3 Department of Stem Cell and Regenerative Medicine Institute of Health Science Mersin University Mersin Turkey Received Accepted Published Online Final Version Abstract 3-acetyl coumarin derivatives 1a-d are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds 2a-d in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance NMR . The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 prostate carcinoma cell lines. Key words Coumarin selenophene antitumor agents antioxidant activity heterocycles 1. Introduction Cancer is a disease that occurs in any part of the body and spreads rapidly. It ranks second among the diseases that cause human deaths in the world. About 9 million people die each year from cancer. The most common types of cancer are breast cancer and colorectal cancer in women and lung cancer and prostate cancer in men. Although many drugs have been developed by scientists to treat cancer they cause the cells to show resistance besides their fatal side effects. For this reason demand for new cancer drugs acting with different mechanisms is increasing day by day. Coumarin compounds are .