tailieunhanh - Influence of subject discontinuation on long-term nonvertebral fracture rate in the denosumab FREEDOM Extension study

Denosumab treatment for up to 8 years in the FREEDOM study and Extension was associated with low fracture incidence. It was not clear whether subjects who discontinued during the study conduct had a higher risk of fracture than those who remained enrolled, thereby underestimating the true fracture risk for the entire trial cohort. |