tailieunhanh - Summary of Material science doctoral thesis: Improving the effective delivery of cisplatin anti cancer drug of dendrimer nanocarrier

Research purpose: Preparation and characterization of nanocarrier systems for drug delivery system based on the modification of dendrimer (PAMAM) with biocompatible surfaces such as PNIPAM and PAA to improve the capping cisplatin. | MINISTRY OF EDUCATION AND VIETNAM ACADEMY OF SCIENCE AND TRAINING TECHNOLOGY GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY NGUYEN NGOC HOA IMPROVING THE EFFECTIVE DELIVERY OF CISPLATIN ANTI CANCER DRUG OF DENDRIMER NANOCARRIER Field of Study Polymer and Composite Code 9 44 01 25 SUMMARY OF MATERIAL SCIENCE DOCTORAL THESIS HO CHI MINH 2020 The thesis was completed at Institute of Applied Materials Science - Graduate University of Science and Technology Vietnam Academy of Science and Technology Supervisor 1 Prof. Dr. Nguyen Cuu Khoa Supervisor 2 Assoc. Prof. Dr. Tran Ngoc Quyen Reviewer 1 Reviewer 2 Reviewer 3 . The thesis shall be defended in front of the Thesis Committee at Academy Level at Institute of Applied Materials Science - Vietnam Academy of Science and Technology At. hour. date. month. 2021 The thesis can be found at - The National Library of Vietnam - The Library of Graduate University of Science and Technology 1 INTRODUCTION 1. The necessity of the thesis Denndrimers were first introduced during the period 1970 1990 by two different groups Buhleier et al and Tomalia et al. Dendrimers are nano-sized radially symmetric molecules with well-defined homogeneous and monodisperse structure consisting of tree-like arms or branches. Dendrimers are nearly mono-disperse macromolecules that contain symmetric branching units built around a small molecule or a linear polymer core. Dendrimers are hyperbranched macromolecules with a carefully tailored architecture the end-groups . the groups reaching the outer periphery which can be functionalized thus modifying their physicochemical or biological properties. Dendrimers are designed to drugs delivery to enhance the pharmacokinetics and biological distribution of the drug and to enhance its target ability. Due to their exquisite structure drug molecules are instantly capped with dendrimer molecules by means of physical adsorption electrostatic interaction covalent binding with the peripheral functional groups or .