tailieunhanh - Summary of Chemitry doctoral thesis: Developing of novel methods for synthesis 1,3-benzazole using sulfur

The research objectives of the thesis: Successfully studied a new multi-component reaction to synthesize 1,3- benzothiazoles using a sulfur agent; new reaction for synthesis of 1,3-benzoxazoles using a sulfur catalyst. | MINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY ----------------------------- Nguyen Le Anh PROJECT NAME Developing of novel methods for synthesis 1 3-benzazole using sulfur Major Organic Chemistry Code 9 44 01 14 SUMMARY OF CHEMITRY DOCTORAL THESIS Ha noi 2021 INSTRODUCTION 1. The urgency of the thesis Benzazoles is one of the important compounds representing a group of heterocyclic compounds with many interesting biological activities. 1 3-benzazoles derivatives have been shown to be active against cancer bacteria and mold 1 2 . In recent years research into new methods of synthesizing derivatives of 1 3- benzazoles has attracted the attention of many scientists in the world. Up to now most of the 1 3-benzazoles synthesis methods have been based on a condensation oxidation reaction that uses the oxidizing effect of oxygen and is catalyzed with different metals. However the use of oxygen as an oxidizer has some drawbacks such as the often poorly selective reaction requiring the presence of a metal catalyst sometimes expensive and the complicated catalytic-type product refining process. The manipulation of gaseous oxygen requires special reactors especially at high temperatures and high pressures. Recently sulfur is being studied for use in many condensation oxidation reactions. Using sulfur as a condensate oxidation reaction agent or catalyst has several advantages such as sulfur as a solid non- hygroscopic durable and non-toxic. Compared to oxygen it is easy to use the exact amount of sulfur in a reaction even at high temperatures. In addition reactions with sulfur can be catalyzed with inexpensive metals and no significant toxicity such as iron molybdenum. With the above advantages sulfur chemistry is an appropriate method with a green environmentally friendly approach. Therefore in order to research and develop some new simple environmentally friendly methods using sulfur we have .