tailieunhanh - báo cáo hóa học:" Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival | Nodin et al. Journal of Ovarian Research 2010 3 14 http content 3 1 14 RESEARCH JOURNAL OF OVARIAN RESEARCH Open Access Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival Bjorn Nodin 1 Nooreldin Zendehrokh1 Jenny Brăndstedt1 2 Elise Nilsson1 Jonas Manjer2 3 Donal J Brennan4 and Karin Jirstrom 1 Abstract Background Altered androgen hormone homeostasis and androgen receptor AR activity have been implicated in ovarian carcinogenesis but the relationship between AR expression in ovarian cancer and clinical outcome remains unclear. Methods In this study the prognostic impact of AR expression was investigated using immunohistochemistry in tissue microarrays from 154 incident cases of epithelial ovarian cancer EOC in the prospective population-based cohorts Malmo Diet and Cancer Study and Malmo Preventive Project. A subset of corresponding fallopian tubes n 36 with no histopathological evidence of disease was also analysed. Results While abundantly expressed in the majority of fallopian tubes with more than 75 positive nuclei in 16 36 44 cases AR was absent in 108 154 70 of EOC cases. AR expression was not related to prognosis in the entire cohort but in the serous subtype n 90 AR positivity 10 positive nuclei was associated with a prolonged disease specific survival in univariate HR 95 CI p and multivariate HR 95 CI p analysis adjusted for age grade and clinical stage. Conclusions AR expression is considerably reduced in EOC as compared to fallopian tubes and in EOC of the serous subtype high AR expression is a favourable prognostic factor. These results indicate that assessment of AR expression might be of value for treatment stratification of EOC patients with serous ovarian carcinoma. Background Epithelial ovarian carcinoma EOC is the second most common and the most lethal malignancy of the female reproductive tract 1 . Etiological factors .