tailieunhanh - A retrospective study for detection of inducible resistance to clindamycin in staphylococcus aureus isolates using D-Test at RIMS teaching hospital, Raichur, India

The present study was conducted for detection of inducible resistance to Clindamycin in Staphylococcus aureus isolates using D – test at Raichur Institute of Medical Sciences-teaching hospital, RAICHUR, Karnataka, India. | 2017 6 10 1537-1542 International Journal of Current Microbiology and Applied Sciences ISSN 2319-7706 Volume 6 Number 10 2017 pp. 1537-1542 Journal homepage http Original Research Article https A Retrospective Study for Detection of Inducible Resistance to Clindamycin in Staphylococcus aureus Isolates Using D-Test at RIMS Teaching Hospital Raichur India R. Venkatesh Naik Basavaraj V. Peerapur and P. Sandhya Department of Microbiology RIMS Raichur Karnataka India Corresponding author ABSTRACT Staphylococcus aureus is recognized as causing nosocomial and community-acquired infections in every region of the world. Clindamycin is considered as useful alternate drug in penicillin-allergic patients in the treatment of skin amp soft tissue infections caused by Staphylococcus aureus. Staphylococcus spp. can be resistant to erythromycin through either erm or msr A genes. Strains with erm-mediated erythromycin resistance may Keywords possess inducible Clindamycin resistance but may appear susceptible to Clindamycin by disc diffusion test. The objective of the present study was to know the prevalence of Clindamycin resistance MRSA erythromycin-induced Clindamycin resistance among clinical isolates of S. aureus. A total MSSA D test. of 160 S. aureus isolates from various clinical samples submitted in the Dept. of Microbiology RIMS teaching hospital Raichur were studied. Methicillin resistant S. Article Info aureus strains were identified by Cefoxitin disc diffusion method. Inducible Clindamycin resistance was detected by erythromycin and Clindamycin disc approximation test D-zone Accepted 14 September 2017 test as per CLSI guidelines. Among the 160 S. aureus isolates 75 strains were Available Online detected as MRSA of which 32 strains showed inducible Clindamycin resistance 10 October 2017 D-test positive and 12 isolates out of 85 strains MSSA were D-test positive. 73 .