tailieunhanh - Khảo sát hoạt chất và hoạt tính kháng sốt rét của cao chiết xà lách (Lactuca sativa)

Bài viết Khảo sát hoạt chất và hoạt tính kháng sốt rét của cao chiết xà lách (Lactuca sativa) trình bày xác định tổng hàm lượng polyphenol (TPC) và hoạt tính kháng sốt rét kháng lại ký sinh trùng sốt rét Plasmodium falciparum (chủng F25-chủng phổ biến ở Việt Nam) của cao chiết ethanol từ xà lách sồi đỏ. | Vietnam Journal of Community Medicine Vol. 64 Special Issue 2023 218-224 INSTITUTE OF COMMUNITY HEALTH ACTIVE INGREDIENTS AND ANTI-MALARIAL EFFECT OF LACTUCA SATIVA ETHANOL EXTRACT IN VITRO Chau Duc Hoa1 Bui Dang Dang Khoa2 Nguyen Manh Khang3 Nguyen Dinh Tri1 Nguyen Huu Duc Minh4 1 Ho Chi Minh City Hospital For Rehabilitation - Professional Diseases - 313 Au Duong Lan 2 ward 8 district Ho Chi Minh city Vietnam 2 Ho Chi Minh City University of Technology Vietnam National University Ho Chi Minh City - 268 Ly Thuong Kiet 14 ward 10 district Ho Chi Minh city Vietnam 3 International University Vietnam National University Ho Chi Minh City - 6 town Thu Duc city Ho Chi Minh city Vietnam 4 University of Medicine and Pharmacy at Ho Chi Minh city - 217 Hong Bang 11 ward 5 district Ho Chi Minh City Vietnam Received 10 01 2023 Revised 13 02 2023 Accepted 02 03 2023 ABSTRACT Objective To determine the total polyphenol content TPC and antimalarial activity against Plasmodium falciparum F25 strain prevalent in Vietnam of ethanol extracts from red oak leaves Lactuca sativa . Research Methodology Ultrasonic bath and UV-Vis spectroscopy were used to determine the TPC. Sesquiterpene lactone which is a compound with potential antimalarial activity by using the KEDDE reagent test and in vitro experiments at the Malaria Institute - Entomology - Parasitology of Ho Chi Minh City. Research Results The highest TPC was found to be mg g mg GAE g of dried oak leaves and compared to the antimalarial drug Artemisinin the extracts showed good antimalarial activity especially the red oak extract showed better activity than the other two extracts. Compared with the 2 Asteraceae plants Artemisia annua L. and Bidens pilosa that were studied red oak extract showed the highest antimalarial activity with an IC50 value of 11 592 ppm. Conclusion Red oak extract has potential for antimalarial and antioxidant activity. Moreover the choice of subject for the research red oak that meets Global and