tailieunhanh - New chlorogenic acid derivatives and triterpenoids from Scorzonera aucheriana

Chromatographic separation of n-hexane and ethyl acetate fraction of a crude methanol extract obtained from aerial parts of the Scorzonera aucheriana DC collected from Sivas province of Turkey yielded nine natural compounds; two new 3-caffeoyl-quinic acid analogs (1-2), one new taraxasterol oleate (3), and six known triterpenoids taraxasterol (4), taraxasterol acetate (5), ptiloepoxide (6), lupeol (7), lupeol acetate (8), and β-sitosterol (9) were characterized. The structures of the isolated compounds were elucidated on the basis of NMR (1H, 13C, COSY, HMBC, HSQC, and TOCSY), UV, FT-IR and LC-Q-TOF-MS spectrometric data. | Turkish Journal of Chemistry Turk J Chem 2021 45 199-209 http chem TÜBİTAK Research Article doi kim-2009-17 New chlorogenic acid derivatives and triterpenoids from Scorzonera aucheriana 1 2 3 1 İshak ERİK Kamil COŞKUNÇELEBİ Serdar MAKBUL Nurettin YAYLI 1 Department of Pharmacognosy Faculty of Pharmacy Karadeniz Technical University Trabzon Turkey 2 Department of Biology Faculty of Science Karadeniz Technical University Trabzon Turkey 3 Department of Biology Faculty of Science and Arts Recep Tayyip Erdoğan University Rize Turkey Received Accepted Published Online Final Version Abstract Chromatographic separation of n-hexane and ethyl acetate fraction of a crude methanol extract obtained from aerial parts of the Scorzonera aucheriana DC collected from Sivas province of Turkey yielded nine natural compounds two new 3-caffeoyl-quinic acid analogs 1-2 one new taraxasterol oleate 3 and six known triterpenoids taraxasterol 4 taraxasterol acetate 5 ptiloepoxide 6 lupeol 7 lupeol acetate 8 and β-sitosterol 9 were characterized. The structures of the isolated compounds were elucidated on the basis of NMR 1H 13C COSY HMBC HSQC and TOCSY UV FT-IR and LC-Q-TOF-MS spectrometric data. Key words Scorzonera aucheriana chlorogenic acid analogs triterpenes 1. Introduction Treatment with plants is as old as human history. Mankind has benefited from natural herbal resources to protect health and treat against diseases. The isolation and characterization of the active compounds found in plants started to develop from the beginning of the 19th century with developing technology. Numerous natural compounds in the scientific process compounds such as morphine penicillin codeine atropine resveratrol and digoxin were isolated from natural sources and took place in the treatment processes. The isolation of the compounds from natural sources and the clarification of their structures are extremely important in the scientific .