tailieunhanh - Characterizing the properties of bisulfite sequencing data: Maximizing power and sensitivity to identify between-group differences in DNA methylation

The combination of sodium bisulfite treatment with highly-parallel sequencing is a common method for quantifying DNA methylation across the genome. The power to detect between-group differences in DNA methylation using bisulfite-sequencing approaches is influenced by both experimental (. read depth, missing data and sample size) and biological (. mean level of DNA methylation and difference between groups) parameters. |

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