tailieunhanh - Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling

A cholesterol-palmitoyl interaction has been reported to occur in the dimeric interface of the b2- adrenergic receptor crystal structure. We sought to investigate whether a similar phenomenon could be observed with μ-opioid receptor (OPRM1), and if so, to assess the role of cholesterol in this class of G protein-coupled receptor (GPCR) signaling. |

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