tailieunhanh - Aurora A site specific TACC3 phosphorylation regulates astral microtubule assembly by stabilizing γtubulin ring complex

Previous studies have demonstrated that human transforming acidic coiledcoil 3 (TACC3), the most conserved TACC family protein, regulates formation of astral microtubules at centrosomes in vertebrate cells by affecting γ-tubulin ring complex (γ-TuRC) assembly. However, the molecular mechanisms underlying such function were not completely understood. |

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