tailieunhanh - Summary of Chemisttry doctoral thesis: Research on the synthesis of hybrid compounds of some triterpenoids containing benzamide and hydroxamate groups

Study on synthesis of hybrid compounds of some triterpenoids containing benzamide and hydroxamate groups in order to search for hybrid compounds with high biological activity, as a scientific basis for further research to create anti-cancer drugs, contribute to health care for the community. | MINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY ------------------ DINH THI CUC SUMMARY OF CHEMISTTRY DOCTORAL THESIS STUDY ON SYNTHESIS OF HYBRID COMPOUNDS OF SOME TRITERPENOIDS CONTAINING BENZAMIDE AND HYDROXAMATE GROUPS Major Organic chemistry Code Hanoi-2020 The thesis was completed in Graduate University Science and Technology Vietnam Academy of Science and Technology. Supervisor . Nguyen Van Tuyen Dr. Le Nhat Thuy Giang Reviewer 1 Reviewer 2 Reviewer 3 The thesis will be presented before the Council for Evaluation of . thesis at the Academy meeting at Graduate University Science and Technology Vietnam Academy of Science at . am .March 2020. A. INTRODUCTION OF THE THESIS 1. The urgency scientific and practical significance of the thesis topic. Cancer is one of the most threatening diseases in the world. Globally an estimated million people died from cancer in 2012 and lung cancer bronchial and tracheal cancer increased significantly has become the fifth leading cause of death in 2012 killing million men and million women. Currently hybrid structured drugs are increasingly being studied and synthesized by scientists to create hybrid compounds with high biological activity that are superior to the original ones. Combining biologically active components to create new structures with exciting activities is currently a research direction that attracts the attention of many scientists. Triterpenoids are a group of natural compounds or their derivatives that have received significant research interest from scientists in recent years. Many tritecpenoid compounds such as betulin betulinic acid ursolic acid oleanolic acid have been declared to have anti-HIV antibacterial antifungal anti-inflammatory and anti-cancer activity. Besides benzamide compounds such as MS-275 MGCD- 0103 are interesting bioactive compounds has been approved by the US Food and Drug .

• Thạc sĩ - Tiến sĩ - Cao học
• Organic chemistry
• Summary of Chemisttry doctoral thesis
• Chemisttry doctoral thesis
• Hydroxamate groups
• Anti cancer drugs
• Vietnamese breast cancer cells
• Breast cancer
• Several anticancer drugs
• Multidrug resistant
• Cancer cells
• Natural products
• Natural drugs
• Anticancer potential of natural drugs
• Hispolon and limonene
• Journal of Chemistry
• Piperazine chemistry
• Structural features
• Anticancer activity
• Anticancer drugs
• D cyclin dependent kinase
• BMC Cancer
• Drug drug interactions
• Drug herb interactions
• Drug food interactions
• Colon cancer
• Oxidative stress
• Modern bioinorganic
• Anticancer drug
• Pivotal trial
• Response rate
• Single arm trial
• Pancreatic cancer
• Virtual screening
• Therapeutic drugs
• PDE6δ transports KRas4B
• biological applications
• biopharmaceuticals
• proteins occurs
• potential effect
• anticancer therapy
• capillary electrophoresis
• Cancer Cell Lines
• Cancer Methylome
• Methylome Analysis
• Novel Genetic
• Genetic Aberrations
• Pluronic – grafted copolymers
• Grafted copolymers as nanoplatforms
• Effectively delivering hydrophobic anticancer drugs
• Innovative development
• Drug development
• Clinical trials
• Drug approval
• Immune checkpoint inhibitors
• United states food
• Drug administration
• Journal of Biology
• Epigenetic modifications
• RNA epigenetic
• Cancer stem cells
• Tumor initiating cells
• Structure–activity
• Molecular docking
• Hybrid anticancer drugs
• Quantitative structure–activity relationship (QSAR)
• Multiple linear regression
• Thymidine phosphorylase
• Platelet derived endothelial cell growth factor (PDECGF)
• Thymidine phosphorylase inhibitors
• Inhibitor design
• Environmental advances
• Fesh water
• Fresh water
• OECD guidelines
• High concentrations employed
• BMC Veterinary Research
• Alpha 2u globulin
• Diabetic kidney disease
• Mesangial expansion
• Chemotherapy induced peripheral neuropathy
• Neurotoxic anticancer drugs
• Chemotherapy regimen
• Radicular systematization
• Application oriented basic
• Nanomedicine in Vietnam
• Promising results
• Drug delivery
• Dendrimer based anticancer drugs
• BMC Chemistry
• Isocitrate lyase
• Pantothenate synthetase
• Mycobacterium tuberculosis H37Rv
• Antifungal drugs
• Chromatography A
• Enantioselective separation
• Nonstandard solvents
• Reversed phase