tailieunhanh - Disentangling evolutionary signals: Conservation, specificity determining positions and coevolution. Implication for catalytic residue prediction

A large panel of methods exists that aim to identify residues with critical impact on protein function based on evolutionary signals, sequence and structure information. However, it is not clear to what extent these different methods overlap, and if any of the methods have higher predictive potential compared to others when it comes to, in particular, the identification of catalytic residues (CR) in proteins. |

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