tailieunhanh - báo cáo hóa học:" Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa: implications for clinical research and audit of care"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa: implications for clinical research and audit of care | Kiragga et al. Journal of the International AIDS Society 2011 14 3 http content 14 1 3 JOURNALOF THE INTERNATIONAL AIDS SOCIETY RESEARCH Open Access Quality of data collection in a large HIV observational clinic database in sub-Saharan Africa implications for clinical research and audit of care 1 1 1 1 Agnes N Kiragga Barbara Castelnuovo Petra Schaefer Timothy Muwonge Philippa J Easterbrook Abstract Background Observational HIV clinic databases are now widely used to answer key questions related to HIV care and treatment but there has been no systematic evaluation of their quality of data. Our objective was to evaluate the completeness and accuracy of recording of key data HIV items in a large routine observational HIV clinic database. Methods We looked at the number and rate of opportunistic infections OIs per 100 person years at risk in the 24 months following antiretroviral therapy ART initiation in 559 patients who initiated ART in 2004-2005 and enrolled into a research cohort. We compared this with data in a routine clinic database for the same 559 patients and a further 1233 patients who initiated ART in the same period. The Research Cohort database was considered as the reference gold standard for the assessment of data accuracy. A crude percentage of underreporting of OIs in the clinic database was calculated based on the difference between the OI rates reported in both databases. We reviewed 100 clinic patient medical records to assess the accuracy of recording of key data items of OIs ART toxicities and ART regimen changes. Results The overall incidence rate per 100 person years at risk for the initial OI in the 559 patients in the research cohort and clinic databases was 95 CI and 95 CI respectively and 95 CI for the 1233 clinic patients. This represents a and higher rate of events in the research cohort database compared with the same 599 patients and 1233 patients in the .