tailieunhanh - Báo cáo y học: " Stimulation of MAP kinase pathways after maternal IL-1β exposure induces fetal lung fluid absorption in guinea pigs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Stimulation of MAP kinase pathways after maternal IL-1β exposure induces fetal lung fluid absorption in guinea pigs. | Respiratory Research BioMed Central Research Stimulation of MAP kinase pathways after maternal IL-1 p exposure induces fetal lung fluid absorption in guinea pigs Reshma Bhattacharjee11 Tianbo Li 1 Shyny Koshy1 LaMonta L Beard1 Kapil Sharma1 Ethan P Carter2 Chrystelle Garat2 and Hans G Folkesson 1 Open Access Address Department of Physiology and Pharmacology Northeastern Ohio Universities College of Medicine Rootstown OH 44272-0095 USA and 2S M Cardiovascular Pulmonary Research University of Colorado Health Science Center Denver CO 80262 USA Email Reshma Bhattacharjee - Tianbo Li - tli1@ Shyny Koshy - skoshy@ LaMonta L Beard - lbeard@ Kapil Sharma - ksharma@ Ethan P Carter - Chrystelle Hans G Folkesson - hgfolkes@ Corresponding author fEqual contributors Published 26 March 2007 Received 31 August 2006 Respiratory Research 2007 8 27 doi 1465-9921 -8-27 Accepted 26 March 2007 This article is available from http content 8 1 27 2007 Bhattacharjee et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background We tested the hypothesis that maternal interleukin-1 p IL-1P pretreatment and induction of fetal cortisol synthesis activates MAP kinases and thereby affects lung fluid absorption in preterm guinea pigs. Methods IL-1 p was administered subcutaneously daily to timed-pregnant guinea pigs for three days. Fetuses were obtained by abdominal hysterotomy and instilled with isosmolar 5 albumin into the lungs and lung fluid movement was measured over 1 h by mass balance. MAP