tailieunhanh - Psychoneuroimmunology and Psychosomatic Medicine: Back to the Future

At the time of Atreya and Dhanwantri (seventh century BC), surgery was considered one of the best methods of treatment for arbuda. They found that herbal medicine treatments against cancer, either in the form of granthi or arbuda, were beneficial only in the beginning stage. Nonetheless, they recorded a group of successful treat- ments for use against gulmas (cystic tumors) and neoplasms of individual organs. 6,7,9–11 Surgical treatment included external and internal cleansing, surgical opening and drainage of the tumor, surgical excision of the tumor, cauterization with alkalis and acids to prevent recurrences, and postoperative care for healing of the wounds. Six types of surgical operations were described: incision, puncturing, excision, scraping, scarification, and suturing | Psychoneuroimmunology and Psychosomatic Medicine Back to the Future Janice K. Kiecolt-Glaser PhD Lynanne McGuire PhD Theodore F. Robles BS and Ronald Glaser PhD Objective Although psychological modulation of immune function is now a well-established phenomenon much of the relevant literature has been published within the last decade. This article speculates on future directions for psychoneuroimmunology research after reviewing the history of the field. Methods This review focuses on human psychoneuroimmunology studies published since 1939 particularly those that have appeared in Psychosomatic Medicine. Studies were clustered according to key themes including stressor duration and characteristics laboratory stressors time-limited naturalistic stressors or chronic stress as well as the influences of psychopathology personality and interpersonal relationships the responsiveness of the immune system to behavioral interventions is also addressed. Additionally we describe trends in populations studied and the changing nature of immunological assessments. The final section focuses on health outcomes and future directions for the field. Results There are now sufficient data to conclude that immune modulation by psychosocial stressors or interventions can lead to actual health changes with the strongest direct evidence to date in infectious disease and wound healing. Furthermore recent medical literature has highlighted a spectrum of diseases whose onset and course may be influenced by proinflammatory cytokines from cardiovascular disease to frailty and functional decline proinflam-matory cytokine production can be directly stimulated by negative emotions and stressful experiences and indirectly stimulated by chronic or recurring infections. Accordingly distress-related immune dysregulation may be one core mechanism behind a diverse set of health risks associated with negative emotions. Conclusions We suggest that psychoneuroimmunology may have broad implications for the .