tailieunhanh - Allele-specific analysis of cell fusionmediated pluripotent reprograming reveals distinct and predictive susceptibilities of human X-linked genes to reactivation

Inactivation of one X chromosome is established early in female mammalian development and can be reversed in vivo and in vitro when pluripotency factors are re-expressed. The extent of reactivation along the inactive X chromosome (Xi) and the determinants of locus susceptibility are, however, poorly understood. |

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