tailieunhanh - Inflammation‑scores as prognostic markers of overall survival in lung cancer: A register‑based study of 6,210 Danish lung cancer patients

Information-scores based on general inflammation markers are suggested as prognostic markers of overall survival (OS) in lung cancer. However, whether these inflammation-scores improves the prognostication per‑ formed by well-established prognostic markers is unsettled. In a large register-based lung cancer patient cohort, nine diferent inflammation-scores were compared, and their ability to optimize the prognostication of OS was evaluated. | Winther Larsen et al. BMC Cancer 2022 22 63 https s12885-021-09108-5 RESEARCH Open Access Inflammation scores as prognostic markers of overall survival in lung cancer a register based study of 6 210 Danish lung cancer patients Anne Winther Larsen1 Ninna Aggerholm Pedersen2 and Birgitte Sandfeld Paulsen1 3 Abstract Background Inflammation-scores based on general inflammation markers are suggested as prognostic markers of overall survival OS in lung cancer. However whether these inflammation-scores improves the prognostication per formed by well-established prognostic markers is unsettled. In a large register-based lung cancer patient cohort nine different inflammation-scores were compared and their ability to optimize the prognostication of OS was evaluated. Methods Lung cancer patients diagnosed from 2009 2018 in The Central Denmark Region were identified in the Danish Lung Cancer Registry. Pre-treatment inflammation markers were extracted from the clinical laboratory information system. Prognostication of OS was evaluated by Cox proportional hazard models. Comparison of the inflammation-scores and their added value to established prognostic markers were assessed by Akaike s information criteria and Harrel s C-index. Results In total 5 320 patients with non-small cell lung cancer NSCLC and 890 patients with small cell lung cancer SCLC were identified. In NSCLC the Aarhus composite biomarker score ACBS including albumin C-reactive protein neutrophil count lymphocyte count and haemoglobin and the neutrophil-lymphocyte-ratio NLR were superior. Furthermore they improved the prognostication of OS significantly p Winther Larsen et al. BMC Cancer 2022 22 63 Page 2 of 10 proven clinically relevant. The tumor node and metasta- included if they were diagnosed with lung cancer reg- sis TNM staging system which classifies patients into istered in The Central Denmark Region and the Danish clinical and pathological stages 3 and the Eastern coop- Lung Cancer .

• Y khoa - Dược
• BMC Cancer
• Lung cancer
• Inflammation score
• Neutrocyte lymphocyte raio
• Modified glasgow prognostic score
• Aarhus composite biomarker score
• Combined NLR and GPS
• Cancer patient pathways
• Colorectal cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study