tailieunhanh - Báo cáo khoa học: " SemiIntensity modulated radiotherapy (IMRT) in benign giant cell tumors – a single institution case series and a short review of the literatur"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: SemiIntensity modulated radiotherapy (IMRT) in benign giant cell tumors – a single institution case series and a short review of the literature. | Roeder et al. Radiation Oncology 2010 5 18 http content 5 1 18 RADIATION ONCOLOGY RESEARCH Open Access Intensity modulated radiotherapy IMRT in benign giant cell tumors - a single institution case series and a short review of the literature Falk Roeder1 2 Carmen Timke1 2 Felix Zwicker1 2 Christian Thieke 1 Marc Bischof1 Jurgen Debus1 Peter E Huber1 2 Abstract Background Giant cell tumors are rare neoplasms representing less than 5 of all bone tumors. The vast majority of giant cell tumors occurs in extremity sites and is treated by surgery alone. However a small percentage occurs in pelvis spine or skull bones where complete resection is challenging. Radiation therapy seems to be an option in these patients despite the lack of a generally accepted dose or fractionation concept. Here we present a series of five cases treated with high dose IMRT. Patients and Methods From 2000 and 2006 a total of five patients with histologically proven benign giant cell tumors have been treated with IMRT in our institution. Two patients were male three female and median age was 30 years range 20 - 60 . The tumor was located in the sacral region in four and in the sphenoid sinus in one patient. All patients had measurable gross disease prior to radiotherapy with a median size of 9 cm. All patients were treated with IMRT to a median total dose of 64 Gy range Gy to 66 Gy in conventional fractionation. Results Median follow up was 46 months ranging from 30 to 107 months. Overall survival was 100 . One patient developed local disease progression three months after radiotherapy and needed extensive surgical salvage. The remaining four patients have been locally controlled resulting in a local control rate of 80 . We found no substantial tumor shrinkage after radiotherapy but in two patients morphological signs of extensive tumor necrosis were present on MRI scans. Decline of pain and or neurological symptoms were seen in all four locally controlled patients. The .