tailieunhanh - Breast-cancer detection using blood-based infrared molecular fingerprints

Breast cancer screening is currently predominantly based on mammography, tainted with the occurrence of both false positivity and false negativity, urging for innovative strategies, as effective detection of early-stage breast cancer bears the potential to reduce mortality. | Kepesidis et al. BMC Cancer 2021 21 1287 https s12885-021-09017-7 RESEARCH Open Access Breast-cancer detection using blood-based infrared molecular fingerprints Kosmas V. Kepesidis1 2 Masa Bozic Iven1 Marinus Huber1 2 Nashwa Abdel Aziz3 Sharif Kullab3 Ahmed Abdelwarith3 Abdulrahman Al Diab3 Mohammed Al Ghamdi3 Muath Abu Hilal3 Mohun R. K. Bahadoor4 Abhishake Sharma4 Farida Dabouz4 Maria Arafah5 Abdallah M. Azzeer6 Ferenc Krausz1 2 Khalid Alsaleh3 Mihaela Zigman1 2 and Jean Marc Nabholtz1 3 Abstract Background Breast cancer screening is currently predominantly based on mammography tainted with the occur rence of both false positivity and false negativity urging for innovative strategies as effective detection of early-stage breast cancer bears the potential to reduce mortality. Here we report the results of a prospective pilot study on breast cancer detection using blood plasma analyzed by Fourier-transform infrared FTIR spectroscopy a rapid cost-effec tive technique with minimal sample volume requirements and potential to aid biomedical diagnostics. FTIR has the capacity to probe health phenotypes via the investigation of the full repertoire of molecular species within a sample at once within a single measurement in a high-throughput manner. In this study we take advantage of cross-molecu lar fingerprinting to probe for breast cancer detection. Methods We compare two groups 26 patients diagnosed with breast cancer to a same-sized group of age-matched healthy asymptomatic female participants. Training with support-vector machines SVM we derive classification models that we test in a repeated 10-fold cross-validation over 10 times. In addition we investigate spectral informa tion responsible for BC identification using statistical significance testing. Results Our models to detect breast cancer achieve an average overall performance of in terms of area under the curve AUC of the receiver operating characteristic ROC . In addition we uncover a .

• Y khoa - Dược
• BMC Cancer
• Breast cancer
• Infrared spectroscopy
• Liquid biopsy
• Receiver operating characteristic
• Measured infrared fingerprints
• Tumor progression
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study