tailieunhanh - Giá trị tiên lượng của thang điểm SNAP-II trong bệnh lý tăng áp phổi dai dẳng ở trẻ sơ sinh

Tăng áp động mạch phổi dai dẳng ở trẻ sơ sinh (Persistent Pulmonary Hypertension of the Newborn- PPHN) là một bệnh lý nặng liên quan đến sự thích nghi của tuần hoàn phổi ngay sau sinh. Mục tiêu nghiên cứu là đánh giá khả năng tiên lượng của thang điểm SNAP-II đến kết quả điều trị bệnh lý PPHN. | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 37 No. 3 2021 89-95 Original Article Predicting Outcome in Persistent Pulmonary Hypertension of the Newborn with Score for Neonatal Acute Physiology- Version II SNAP-II Nguyen Huu Hieu1 Tran Minh Dien2 Le Thi Ha2 1 Hanoi Medical University 1 Ton That Tung Dong Da Hanoi Vietnam 2 Vietnam National Children s Hospital 18 879 La Thanh Dong Da Hanoi Vietnam Received 18 May 2021 Revised 30 May 2021 Accepted 30 May 2021 Abstract Persistent pulmonary hypertension of the Newborn is a serious disease related to the adaptation of fetal circulation after birth. This study aims to determine the ability of Score for Neonatal Acute Physiology- version II SNAP-II for predicting outcome in neonates with persistent pulmonary hypertension of the newborn PPHN . This prospective cohort study of 52 neonates with PPHN was carried out in the Neonatal Center and Surgical Intensive Care Unit Vietnam National Children s Hospital over a period of 7 months 10 2020 to 4 2021 . SNAP-II score was evaluated within the first 12 hours of admission. Outcome of treatment was recorded at the 28th day of treatment. The study results show that the mortality rate was of the patients had to use ventilators of the patients used NO inhalers and 9 6 of the patients required ECMO. SNAP-II score has the power of predicting mortality in PPHN with the area under the ROC curve of 95 CI 092 p lt . SNAP-II score 27 was calculated as cutoff for predicting mortality with the sensitivity of 92 3 and specificity of . Each point increase in SNAP-II score increased the odd of mortality by 95 CI p lt . SNAP-II score also has the ability of predicting secondary outcome of PPHN using ECMO AUC . Notably this study finds that the SNAP-II scoring system is a useful and reliable tool to predict mortality of neonates with PPHN and to assess the need of ECMO therapy. Keywords Persistent pulmonary .