tailieunhanh - Investigation of serum TNF-Alpha and IL-6 concentrations in patients with long term hemodialysis

Objectives: To investigate serum TNF-α and IL-6 concentration in long-term hemodialysis patients (LHD) and find out the association between serum TNF-α and IL-6 concentration and some characteristics of LHD patients. | Journal of military pharmaco-medicine no2-2018 INVESTIGATION OF SERUM TNF-ALPHA AND IL-6 CONCENTRATIONS IN PATIENTS WITH LONG-TERM HEMODIALYSIS Nguyen Duc Loc*; Ha Hoang Kiem**; Vu Xuan Nghia*** SUMMRAY Objectives: To investigate serum TNF-α and IL-6 concentration in long-term hemodialysis patients (LHD) and find out the association between serum TNF-α and IL-6 concentration and some characteristics of LHD patients. Subjects and methods: A prospective, cross-sectional study in 107 LHD patients who treated at Hemodialysis Department, An Sinh Hospital from 2 - 2014 to 2 - 2017 and a control group of 51 healthy people. Urinary NGAL concentration had been measured in all 116 patients and healthy people. Results: TNF-α and IL-6 concentrations in study group were significantly higher than those in the control group with p . - Mean value of IL-6 concentration increased with time of dialysis. There was a statistically significant association between IL-6 concentration and dialysis duration (p ). Table 6: Relation between TNF-α and IL-6 concentration and preserved urine output status (n = 107). Status TNF-α (ng/L) IL-6 (ng/L) Preserved urine output (n = 81) ± ± Non-preserved urine output (n = 26) ± ± . - IL-6 concentration was significantly higher in preserved urine output patients compared with non-preserved urine output patients (p . - Elevated proportion of IL-6 concentration was significantly higher in decreased albumin group compared with non-decreased group ( versus ) with p < . DISCUSSION Chronic inflammation is high prevalent in LHD patients, which is a strong independent predictor of all causes and CVD mortality in those population [4]. It may explain the excess CVD risk in LHD patients, in whom inflammation is common. Certain pro-inflammatory cytokines, such as IL-6 and TNF-a, are considered as early drivers of the inflammatory response. When comparing the study group .