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Báo cáo y học: "Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis"

Wu et al. Arthritis Research & Therapy 2011, 13:R62 http://arthritis-research.com/content/13/2/R62 Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis. | Wu et al. Arthritis Research Therapy 2011 13 R62 http arthritis-research.eom content 13 2 R62 RESEARCH ARTICLE Open Access Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis 1.4 1 2 2 2 3 Jun Wu Carl Ekman Andreas Jonsen Gunnar Sturfelt Anders A Bengtsson Anders Gottsater Bengt Lindblad3 Elisabet Lindqvist2 Tore Saxne2 and Bjorn Dahlback1 Abstract Introduction Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl they constitute the TAM receptor family. These receptors can be shed from the cell membrane and their soluble extracellular regions can be found in plasma. The objective of this study was to elucidate whether the plasma levels of soluble Mer sMer and Tyro3 sTyro3 were increased in systemic lupus erythematosis SLE rheumatoid arthritis RA or critical limb ischemia CLI . Methods ELISA kits were used to test plasma concentrations in controls and in patients with SLE RA or CLI. Results Increased levels of in particular sMer and to some extent sTyro3 were found in patients with SLE or RA but not in patients with CLI. Patients with SLE demonstrated the highest sMer levels and there was a strong correlation to higher SLE disease activity score SLEDAI . In contrast in patients with RA the sMer levels did not correlate with the disease activity score DAS . In SLE sMer levels were particularly high in those with lupus nephritis patients who also had decreased C1q levels and increased titers of anti-DNA antibodies. After therapy the plasma concentrations of sMer decreased in parallel to the decrease in SLEDAI score. Conclusions The plasma concentrations of sMer and sTyro3 were significantly increased in patients with active SLE and RA suggesting the TAM receptor shedding was affected by these autoimmune diseases. In particular sMer was increased in SLE the plasma levels of sMer reflecting disease activity. Introduction .