tailieunhanh - Báo cáo y học: " Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus. | Anania et al. Arthritis Research Therapy 2010 12 R214 http content 12 6 R214 RESEARCH ARTICLE Open Access Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus Cristina Anania 1 Thomas Gustafsson Xiang Hua 1 Jun Su 1 Max Vikstrom Ulf de Faire Mikael Heimburger1 Tomas Jogestrand2 3 Johan Frostegard1 2 5 Abstract Introduction The risk of cardiovascular disease CVD and atherosclerosis is reported to be increased in systemic lupus erythematosus SLE . We recently reported a negative association between natural IgM-antibodies against phosphorylcholine anti-PC in the general population high anti-PC levels leading to decreased atherosclerosis development and low levels to increased risk of CVD. Potential mechanisms include anti-inflammatory properties and inhibition of uptake of oxidized low density lipoprotein LDL in macrophages. The objective herein was to study atherosclerosis in SLE in detail and in relation to traditional and non-traditional risk factors. Methods A total of 114 patients with SLE were compared with 122 age- and sex-matched population-based controls. Common carotid intima-media thickness IMT calculated intima-media area cIMa and plaque occurrence were determined by B-mode ultrasound as a surrogate measure of atherosclerosis. Plaques were graded according to echogenicity and grouped as 1 to 4 with 1 being echoluscent and considered most vulnerable. Anti-PC was studied by ELISA. Results Hypertension triglycerides and insulin resistance determined by homeostasis model assessment of insulin resistance and C-reactive protein CRP were increased in SLE P while smoking LDL high density lipoprotein HDL did not differ between groups. Low levels of anti-PC IgM lowest tertile were more common in SLE patients than in controls P . IMT and cIMa did not differ significantly between groups. .