tailieunhanh - Báo cáo y học: "(Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: (Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis. | den Uyl et al. Arthritis Research Therapy 2011 13 R5 http content 13 1 R5 RESEARCH ARTICLE Open Access Sub clinical cardiovascular disease is associated with increased bone loss and fracture risk a systematic review of the association between cardiovascular disease and osteoporosis 1 1 1 Debby den Uyl Mike T Nurmohamed Lilian HD van Tuyl Hennie G Raterman Willem F Lems Abstract Introduction Both cardiovascular disease and osteoporosis are important causes of morbidity and mortality in the elderly. The co-occurrence of cardiovascular disease and osteoporosis prompted us to review the evidence of an association between cardiovascular CV disease and osteoporosis and potential shared common pathophysiological mechanisms. Methods A systematic literature search Medline Pubmed and Embase was conducted to identify all clinical studies that investigated the association between cardiovascular disease and osteoporosis. Relevant studies were screened for quality according to guidelines as proposed by the Dutch Cochrane Centre and evidence was summarized. Results Seventy studies were included in this review. Due to a large heterogeneity in study population design and outcome measures a formal meta-analysis was not possible. Six of the highest ranked studies mean n 2 000 showed that individuals with prevalent subclinical CV disease had higher risk for increased bone loss and fractures during follow-up compared to persons without CV disease range of reported risk hazard ratio HR odds ratio OR to . The largest study n 31 936 reported a more than four times higher risk in women and more than six times higher risk in men. There is moderate evidence that individuals with low bone mass had higher CV mortality rates and incident CV events than subjects with normal bone mass risk rates to . Although the shared common pathophysiological mechanisms are not fully elucidated the most important factors that might explain this association .