Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers"
Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. | Available online http arthritis-research.eom 4 6 R11 Research article Angiogenic and angiostatic factors in systemic sclerosis increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers Oliver Distler1 Angela del Rosso2 Roberto Giacomelli3 Paola Cipriani3 Maria L Conforti2 Serena Guiducci2 Renate E Gay1 Beat A Michel1 Pius Bruhlmann1 Ulf Muller-Ladner4 Steffen Gay1 and Marco Matucci-Cerinic2 Center of Experimental Rheumatology Department of Rheumatology University Hospital Zurich Switzerland 2Department of Medicine Section of Rheumatology University of Florence Italy 3Department of Internal Medicine and Public Health University of L Aquila Italy 4Department of Internal Medicine I University of Regensburg Germany Corresponding author Steffen Gay e-mail Steffen.Gay@ruz.usz.ch Received 14 May 2002 Revisions received 30 July 2002 Accepted 6 August 2002 Published 30 August 2002 Arthritis Res 2002 4 R11 DOI 10.1186 ar596 2002 Distler et al. licensee BioMed Central Ltd Print ISSN 1465-9905 Online ISSN 1465-9913 Abstract To examine whether the lack of sufficient neoangiogenesis in systemic sclerosis SSc is caused by a decrease in angiogenic factors and or an increase in angiostatic factors the potent proangiogenic molecules vascular endothelial growth factor VEGF and basic fibroblast growth factor and the angiostatic factor endostatin were determined in patients with SSc and in healthy controls. Forty-three patients with established SSc and nine patients with pre-SSc were included in the study. Serum levels of VEGF basic fibroblast growth factor and endostatin were measured by ELISA. Age-matched and sex-matched healthy volunteers were used as controls. Highly significant differences were found in serum levels of VEGF between SSc patients and healthy controls whereas no differences could be detected for endostatin and basic fibroblast growth factor. Significantly higher levels .