tailieunhanh - Báo cáo y học: "The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. | Protein family review The vascular endothelial growth factor VEGF family angiogenic factors in health and disease David IR Holmes 4 and Ian Zachary Addresses BHF Laboratories and The Rayne Institute Department of Medicine University College London 5 University Street London WC1E 6JJ UK. ỲArk Therapeutics Ltd 1 Fitzroy Mews London W1T 6DE UK. Correspondence Ian Zachary. E-mail Published I February 2005 Genome Biology 2005 6 209 The electronic version of this article is the complete one and can be found online at http 2005 6 2 209 2005 BioMed Central Ltd Summary Vascular endothelial growth factors VEGFs are a family of secreted polypeptides with a highly conserved receptor-binding cystine-knot structure similar to that of the platelet-derived growth factors. VEGF-A the founding member of the family is highly conserved between animals as evolutionarily distant as fish and mammals. In vertebrates VEGFs act through a family of cognate receptor tyrosine kinases in endothelial cells to stimulate blood-vessel formation. VEGF-A has important roles in mammalian vascular development and in diseases involving abnormal growth of blood vessels other VEGFs are also involved in the development of lymphatic vessels and disease-related angiogenesis. Invertebrate homologs of VEGFs and VEGF receptors have been identified in fly nematode and jellyfish where they function in developmental cell migration and neurogenesis. The existence of VEGF-like molecules and their receptors in simple invertebrates without a vascular system indicates that this family of growth factors emerged at a very early stage in the evolution of multicellular organisms to mediate primordial developmental functions. The formation of a vascular system is a prerequisite for vertebrate embryogenesis and involves two fundamental processes vasculogenesis defined as the differentiation of endothelial cell progenitors and their assembly into the primary capillary plexus and .