tailieunhanh - Báo cáo y học: "Endothelial cell phenotypes in the rheumatoid synovium: activated, angiogenic, apoptotic and leaky"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Endothelial cell phenotypes in the rheumatoid synovium: activated, angiogenic, apoptotic and leaky. | Arthritis Research Therapy Vol 6 No 2 Middleton et al. Review Endothelial cell phenotypes in the rheumatoid synovium activated angiogenic apoptotic and leaky Jim Middleton1 Laure Americh1 Regis Gayon1 Denis Julien1 Luc Aguilar1 Francois Amalric1 2 and Jean-Philippe Girard1 2 1Endocube . Prologue Biotech Labege cedex France 2Laboratoire de Biologie Vasculaire Equipe Labellisée LA LIGUE 2003 IPBS-CNRS UMR 5089 Toulouse cedex France Corresponding author Jim Middleton e-mail Received 3 Nov 2003 Revisions requested 3 Dec 2003 Revisions received 28 Jan 2004 Accepted 4 Feb 2004 Published 8 Mar 2004 Arthritis Res Ther 2004 6 60-72 DOI ar1156 2004 BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 Abstract Endothelial cells are active participants in chronic inflammatory diseases. These cells undergo phenotypic changes that can be characterised as activated angiogenic apoptotic and leaky. In the present review these phenotypes are described in the context of human rheumatoid arthritis as the disease example. Endothelial cells become activated in rheumatoid arthritis pathophysiology expressing adhesion molecules and presenting chemokines leading to leukocyte migration from the blood into the tissue. Endothelial cell permeability increases leading to oedema formation and swelling of the joints. These cells proliferate as part of the angiogenic response and there is also a net increase in the turnover of endothelial cells since the number of apoptotic endothelial cells increases. The endothelium expresses various cytokines cytokine receptors and proteases that are involved in angiogenesis proliferation and tissue degradation. Associated with these mechanisms is a change in the spectrum of genes expressed some of which are relatively endothelial specific and others are widely expressed by other cells in the synovium. Better knowledge of molecular and functional changes occurring in endothelial cells during chronic inflammation .