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Báo cáo y học: "Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective. | Pate et al. Clinical and Molecular Allergy 2010 8 3 http www.clinicalmolecularallergy.eom content 8 1 3 REVIEW CMA CLINICAL AND MOLECULAR ALLERGY Open Access Regulation and dysregulation of immunoglobulin E a molecular and clinical perspective Mariah B Pate 1 John Kelly Smith1 2 David S Chi2 Guha Krishnaswamy1 2 3 Abstract Background Altered levels of Immunoglobulin E IgE represent a dysregulation of IgE synthesis and may be seen in a variety of immunological disorders. The object of this review is to summarize the historical and molecular aspects of IgE synthesis and the disorders associated with dysregulation of IgE production. Methods Articles published in Medline PubMed were searched with the keyword Immunoglobulin E and specific terms such as class switch recombination deficiency and or specific disease conditions atopy neoplasia renal disease myeloma etc. . The selected papers included reviews case reports retrospective reviews and molecular mechanisms. Studies involving both sexes and all ages were included in the analysis. Results Both very low and elevated levels of IgE may be seen in clinical practice. Major advancements have been made in our understanding of the molecular basis of IgE class switching including roles for T cells cytokines and T regulatory or Treg cells in this process. Dysregulation of this process may result in either elevated IgE levels or IgE deficiency. Conclusion Evaluation of a patient with elevated IgE must involve a detailed differential diagnosis and consideration of various immunological and non-immunological disorders. The use of appropriate tests will allow the correct diagnosis to be made. This can often assist in the development of tailored treatments. Introduction Immunoglobulin E has traditionally been associated with atopic disease and systemic anaphylaxis. However its role in host defense parasitic infection and immune surveillance suggest many other potential functions. The initial description of anaphylaxis was made by