tailieunhanh - Báo cáo y học: "Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions. | CLINICAL PROTEOMICS 10000000 1000000 100000 Down-regulation of kallikrein-related peptidase 5 KLK5 expression in breast cancer patients a biomarker for the differential diagnosis of breast lesions Avgeris et al. Avgeris et al. Clinical Proteomics 2011 8 5 http content 8 1 5 31 May 2011 BioMed Central Avgeris et al. Clinical Proteomics 2011 8 5 http content 8 1 5 CLINICAL PROTEOMICS RESEARCH Open Access Down-regulation of kallikrein-related peptidase 5 KLK5 expression in breast cancer patients a biomarker for the differential diagnosis of breast lesions Margaritis Avgeris1 Georgia Papachristopoulou1 2 Athanasios Polychronis2 and Andreas Scorilas1 Correspondence ascorilas@biol. department of Biochemistry and Molecular Biology University of Athens Panepistimiopolis 15701 Athens Greece Full list of author information is available at the end of the article Abstract Background Kallikrein-related peptidase 5 KLK5 is a secreted trypsin-like protease of the KLK family encoded by the KLK5 gene. KLK5 has been found to cleave various extracellular matrix components as well as to activate several other KLK proteases triggering the stimulation of tissue microenvironment proteolytic cascades. Material and Methods KLK5 expression levels were quantified in 102 cancerous and benign breast tissue specimens obtained by randomly chosen patients using RT-qPCR assay. Subsequently advanced biostatistics were applied in order to analyze the KLK5 expression profile in the two patients cohorts and also to evaluate its clinical significance for the discrimination of breast tumors. Results A statistically significant p down-regulation of the KLK5 expression levels were observed in the malignant specimens compared to the benign ones. Logistic regression and ROC curve analysis revealed the significant p and the independent p value of the KLK5 expression quantification for the discrimination of the .