tailieunhanh - Báo cáo y học: "Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway. | Clinical and Molecular Allergy BioMed Central Research Baicalein inhibits IL-1 p- and TNF-a-induced inflammatory cytokine production from human mast cells via regulation of the NF-kB pathway Chia-Jung Hsieh1 Kenton Hall1 Tuanzhu Ha2 Chuanfu Li2 Guha Krishnaswamy1 and David S Chi 1 Address Departments of Internal Medicine James H. Quillen College of Medicine East Tennessee State University Johnson City Tennessee 37614 USA and 2Departmen of Surgery James H. Quillen College of Medicine East Tennessee State University Johnson City Tennessee 37614 USA Email Chia-Jung Hsieh - hsiehcj3@ Kenton Hall - hallh@ Tuanzhu Ha - ha@ Chuanfu Li - li@ Guha Krishnaswamy - Krishnas@ David S Chi - chi@ Corresponding author Open Access Published 26 November 2007 Received 26 September 2007 r r Accepted 26 November 2007 Clinical and Molecular Allergy 2007 5 5 doi 1476-7961-5-5 This article is available from http content 5 1 5 2007 Hsieh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human mast cells are multifunctional cells capable of a wide variety of inflammatory responses. Baicalein BAI isolated from the traditional Chinese herbal medicine Huangqin Scutellaria baicalensis Georgi has been shown to have anti-inflammatory effects. We examined its effects and mechanisms on the expression of inflammatory cytokines in an IL-ip- and TNF-a-activated human mast cell line HMC-1. Methods HMC-i cells were stimulated either with IL-ip 10 ng ml or TNF-a 100 U ml in the presence or absence of BAI. We assessed the expression of IL-6 IL-8 and MCP-i by ELISA .