tailieunhanh - Báo cáo y học: " Signaling and regulation of G protein-coupled receptors in airway smooth muscle"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Signaling and regulation of G protein-coupled receptors in airway smooth muscle | Respiratory Research BioMed Central Review Open Access Signaling and regulation of G protein-coupled receptors in airway smooth muscle Charlotte K Billington and Raymond B Penn Address Department of Medicine Division of Critical Care Pulmonary Allergic Immunologic Diseases and Kimmel Cancer Center Jefferson Medical College Thomas Jefferson University Philadelphia PA 19107 Email Charlotte K Billington - Raymond B Penn - Corresponding author Published 14 March 2003 Received 14 August 2002 Accepted 14 October 2002 Respir Res 2003 4 2 This article is available from http content 4 l 2 2003 Billington et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Signaling through G protein-coupled receptors GPCRs mediates numerous airway smooth muscle ASM functions including contraction growth and synthetic functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition we examine the role of GPCR signaling and its regulation in asthma and asthma treatment and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state. Introduction G protein coupled receptors GPCRs comprise a superfamily of proteins capable of transducing a wide range of extracellular signals across the plasma membrane of the cell into discrete intracellular messages capable of regulating numerous diverse cell functions. Over 800 GPCRs have been cloned to date and over 1000 are suspected in the human genome 1 . The majority .