tailieunhanh - Báo cáo y học: " Down regulation of the high-affinity IgE receptor associated with successful treatment of chronic idiopathic urticaria with omalizuma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Down regulation of the high-affinity IgE receptor associated with successful treatment of chronic idiopathic urticaria with omalizumab. | Saavedra and Sur Clinical and Molecular Allergy 2011 9 2 http content 9 1 2 CMA CLINICAL AND MOLECULAR ALLERGY CASE REPORT Open Access Down regulation of the high-affinity IgE receptor associated with successful treatment of chronic idiopathic urticaria with omalizumab Michael C Saavedra Sanjiv Sur Abstract Chronic idiopathic urticaria is a condition that is often controllable with antihistamine therapy. However some patients have disease burden that is difficult to manage non-responsive to antihistamines and often requires immunosuppressive medications such as corticosteroids or cyclosporine. We present here a study that demonstrates the effectiveness of omalizumab in treating this condition and the temporal relationship between improvement and down regulation of the high affinity IgE receptor FgeRI . For this blood samples were obtained from a symptomatic patient before each treatment and processed for flow cytometric analysis of FceRI levels on the surface of blood basophils. Down regulation of FceRI was observed in association with significant clinical improvement and discontinuation of immunosuppressive medications. Background While approximately 20 of the population will experience an episode of acute urticaria at some point in their lifetime only will experience the scourge of chronic urticaria 1 . This disease is characterized by at least 6 weeks of almost daily episodes of intensely pruritic cutaneous wheals that typically last less than 24 hours and are not associated with residual pigmentation. Half of patients with chronic urticaria are thought to have this disease as a result of autoimmune phenomenon while the remaining patients are designated as having idiopathic disease. It has been estimated that approximately 35-45 of patients possess autoimmune IgG antibodies that target the alpha subunit of FcsRI or to a lesser extent target directly the IgE antibody 2 . A link between thyroid autoimmunity and chronic .