tailieunhanh - Báo cáo y học: "Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease. | Comparative Hepatology BioMed Central Review Open Access Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models relevance for human health and disease Eric Boitier Jean-Charles Gautier and Ruth Roberts Address Aventis Pharma Drug Safety Evaluation Centre de Recherche de Paris 13 Quai Jules Guesde 94403 Vitry sur Seine Paris France Email Eric Boitier - Jean-Charles Gautier - Ruth Roberts - Corresponding author Published 31 January 2003 Received 3 December 2002 Accepted 31 January 2003 Comparative Hepatology 2003 2 3 This article is available from http content 2 l 3 2003 Boitier et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Peroxisome proliferator activated receptors PPARs are a family of related receptors implicated in a diverse array of biological processes. There are 3 main isotypes of PPARs known as PPARa PPARp and PPARy and each is organized into domains associated with a function such as ligand binding activation and DNA binding. PPARs are activated by ligands which can be both endogenous such as fatty acids or their derivatives or synthetic such as peroxisome proliferators hypolipidaemic drugs anti-inflammatory or insulin-sensitizing drugs. Once activated PPARs bind to DNA and regulate gene transcription. The different isotypes differ in their expression patterns lending clues on their function. PPARa is expressed mainly in liver whereas PPARy is expressed in fat and in some macrophages. Activation of PPARa in rodent liver is associated with peroxisome proliferation and with suppression of apoptosis and induction of cell proliferation. The mechanism by which activation of .