tailieunhanh - Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: A multicenter study from China

At present, hepatectomy is still the most common and efective treatment method for intrahepatic cholangiocarcinoma (ICC) patients. However, the postoperative prognosis is poor. Therefore, the prognostic factors for these patients require further exploration. Whether microvascular invasion (MVI) plays a crucial role in the prognosis of ICC patients is still unclear. | Chen et al. BMC Cancer 2021 21 1299 https s12885-021-09035-5 RESEARCH Open Access Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma a multicenter study from China Yifan Chen1 Hongzhi Liu1 Jinyu Zhang1 Yijun Wu1 Weiping Zhou2 Zhangjun Cheng3 Jianying Lou4 Shuguo Zheng5 Xinyu Bi6 Jianming Wang7 Wei Guo8 Fuyu Li9 Jian Wang10 Yamin Zheng11 Jingdong Li12 Shi Cheng13 Yongyi Zeng1 14 and Jingfeng Liu1 Abstract Background At present hepatectomy is still the most common and effective treatment method for intrahepatic cholangiocarcinoma ICC patients. However the postoperative prognosis is poor. Therefore the prognostic factors for these patients require further exploration. Whether microvascular invasion MVI plays a crucial role in the prognosis of ICC patients is still unclear. Moreover few studies have focused on preoperative predictions of MVI in ICC patients. Methods Clinicopathological data of 704 ICC patients after curative resection were retrospectively collected from 13 hospitals. Independent risk factors were identified by the Cox or logistic proportional hazards model. In addition the survival curves of the MVI-positive and MVI-negative groups before and after matching were analyzed. Subsequently 341 patients from a single center Eastern Hepatobiliary Hospital in the above multicenter retrospective cohort were used to construct a nomogram prediction model. Then the model was evaluated by the index of concordance C-Index and the calibration curve. Results After propensity score matching PSM Child-Pugh grade and MVI were independent risk factors for overall survival OS in ICC patients after curative resection. Major hepatectomy and MVI were independent risk factors for recurrence-free survival RFS . The survival curves of OS and RFS before and after PSM in the MVI-positive groups were significantly different compared with those in the MVI-negative groups. Multivariate logistic regression