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Báo cáo y học: "Cerebral perfusion in sepsis-associated delirium"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Cerebral perfusion in sepsis-associated delirium. | Available online http ccforum.eom content 1 2 3 R63 Research Cerebral perfusion in sepsis-associated delirium David Pfister1 Martin Siegemund1 Salome Dell-Kuster1 Peter Smielewski2 Stephan Ruegg3 Stephan P Strebel1 Stephan CU Marsch4 Hans Pargger1 and Luzius A Steiner1 Open Access Department of Anaesthesia Operative Intensive Care Unit University Hospital Basel Spitalstrasse 21 CH-4031 Basel Switzerland 2Academic Neurosurgery Addenbrooke s Hospital Cambridge University Hospitals NHS Foundation Trust Hills Road Cambridge CB2 0QQ UK department of Neurology University Hospital Basel Petersgraben 4 CH-4031 Basel Switzerland 4Medical Intensive Care Unit University Hospital Basel Petersgraben 4 CH-4031 Basel Switzerland Corresponding author Luzius A Steiner lsteiner@uhbs.ch Received 15 Jan 2008 Revisions requested 8 Feb 2008 Revisions received 4 Mar 2008 Accepted 5 May 2008 Published 5 May 2008 Critical Care 2008 12 R63 doi 10.1186 cc6891 This article is online at http ccforum.com content 12 3 R63 2008 Pfister et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The pathophysiology of sepsis-associated delirium is not completely understood and the data on cerebral perfusion in sepsis are conflicting. We tested the hypothesis that cerebral perfusion and selected serum markers of inflammation and delirium differ in septic patients with and without sepsis-associated delirium. Methods We investigated 23 adult patients with sepsis severe sepsis or septic shock with an extracranial focus of infection and no history of intracranial pathology. Patients were investigated after stabilisation within 48 hours after admission to the intensive care unit. Sepsis-associated delirium was diagnosed using the confusion .