tailieunhanh - Báo cáo y học: "Bench-to-bedside review: Burn-induced cerebral inflammation – a neglected entity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Burn-induced cerebral inflammation – a neglected entity? | Available online http content 13 3 215 Review Bench-to-bedside review Burn-induced cerebral inflammation -a neglected entity Michael A Flierl1 Philip F Stahel1-2 Basel M Touban1 Kathryn M Beauchamp2 Steven J Morgan1 Wade R Smith1 and Kyros R Ipaktchi1 1 Department of Orthopaedic Surgery Denver Health Medical Center University of Colorado School of Medicine 777 Bannock Street Denver CO 80204 USA 2Department of Neurosurgery Denver Health Medical Center University of Colorado School of Medicine 777 Bannock Street Denver CO 80204 USA Corresponding author Philip F Stahel Published 29 June 2009 This article is online at http content 13 3 215 2009 BioMed Central Ltd Critical Care 2009 13 215 doi cc7794 Abstract Severe burn injury remains a major burden on patients and healthcare systems. Following severe burns the injured tissues mount a local inflammatory response aiming to restore homeostasis. With excessive burn load the immune response becomes disproportionate and patients may develop an overshooting systemic inflammatory response compromising multiple physiological barriers in the lung kidney liver and brain. If the blood-brain barrier is breached systemic inflammatory molecules and phagocytes readily enter the brain and activate sessile cells of the central nervous system. Copious amounts of reactive oxygen species reactive nitrogen species proteases cytokines chemokines and complement proteins are being released by these inflammatory cells resulting in additional neuronal damage and life-threatening cerebral edema. Despite the correlation between cerebral complications in severe burn victims with mortality burn-induced neuroinflammation continues to fly under the radar as an underestimated entity in the critically ill burn patient. In this paper we illustrate the molecular events leading to blood-brain barrier breakdown with a focus on the subsequent neuroinflammatory changes leading to cerebral edema in .