tailieunhanh - Báo cáo y học: "Pharmacological effects of Salvia miltiorrhiza (Danshen) on cerebral infarction"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Pharmacological effects of Salvia miltiorrhiza (Danshen) on cerebral infarction. | Lin and Hsieh Chinese Medicine 2010 5 22 http content 5 1 22 CHINESE MEDICINE REVIEW Open Access Pharmacological effects of Salvia miltiorrhiza Danshen on cerebral infarction Tsai-Hui Lin 1 and Ching-Liang Hsieh 1 2 3 Abstract Danshen the dried root of Salvia miltiorrhiza is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects which prevent cerebral infarction. Danshen may enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals. Prevention and treatment of cerebral infarction by Danshen involves multiple pathways including anti-atherosclerosis anti-hypertension anti-platelet aggregation antiinflammatory and anti-oxidative effects. Review Background Danshen the dried root of Salvia miltiorrhiza is used in Chinese medicine to treat vascular disease. According to Chinese medicine theory Danshen promotes blood flow and resolves blood stasis. Among stroke patients 80 suffer from cerebral infarction and 20 cerebral hemorrhage 1 . Cerebral infarction is an ischemic condition of the brain including thrombosis embolism or systemic hemodynamic hypotension. Cerebral infarction is often caused by atherosclerosis of large and small arteries. The etiology of atherosclerosis and stroke is related to inflammation and genetic factors. Ischemic cerebral infarction may be prevented through anti-inflammation and treatment for vascular diseases heart diseases and hypertension 2-4 . Anti-thrombosis and thrombolysis are used to treat ischemic cerebral infarction 2 . The most effective method to re-establish cerebral blood flow is thrombolytic therapy however this therapy is .